What is Acetyl Tetrapeptide 5 (Eyeseryl©)? How is it used in skin care?

Research in the field of cosmetic technology has made significant strides in recent years. Some molecules with interesting nutritional and protective properties for the skin have been identified and characterized, such as peptides. In particular, in the field of anti-aging skincare, the most substantial revolution has occurred through peptides. Let's go into more detail.

What are peptides?

Peptides are chains of amino acids essential for the production of collagen, elastin, and keratin. In practice, peptides are the foundation for the creation of the proteins essential for healthy skin, which appears firm, resilient, and strong.

"In the absence of peptides, the skin would be less intact and firm, with an uneven texture and little elasticity. Based on how they act on the skin, peptides have been divided into three groups:"

1. signal peptides, which have the ability to increase the synthesis of collagen and elastin while preventing their degradation;
2. neurotransmitter peptides, which act by undermining the effects of botulinic neurotoxins by relaxing the subcutaneous musculature;
3. vector peptides, capable of providing the trace elements necessary to activate enzymatic processes.

In cosmetics, the use of peptides is very extensive, although it should be noted that a single ingredient is not enough to achieve a total anti-wrinkle effect. Often, peptides must also be combined with other active ingredients and work on the skin supported by specific formulas.

In particular, a peptide widely used in the cosmetic field is Acetyl Tetrapeptide 5: according to a study conducted by Lipotec on a sample of men aged between 30 and 65, Acetyl Tetrapeptide 5 or Eyeseryl©.

it is able to reduce the swelling of under-eye bags by almost 30% in just 28 days.

Acetyl Tetrapeptide 5: what is it? What is it used for?

Acetyl Tetrapeptide 5 is one of the bioactive peptides more commonly known as bioactives because they possess biological activity and can influence the processes that occur in the body. This type of peptide has shown remarkable effectiveness regarding the eye contour area. 

It is said that the eyes are the mirror of the soul, capable of reflecting not only outer beauty but also inner beauty. The eyes are also one of the first areas where signs related to age and fatigue are noticed with the appearance of bags and dark circles. In addition to the obvious aging process, other factors, such as gender, particularly contribute to the presence of puffy eyes.

The eye contour is an area of the face that needs to be treated differently precisely because the skin in this area has particular characteristics: 

• it is 10 times thinner than the skin on the rest of the face; 
• undergoes collagen and elastin degradation more rapidly; 
• subtle presence of corneocytes; 
• poor barrier capacity. 

For these reasons, the eye contour area requires greater attention and a skincare specification. For this reason, the peptide Eyeseryl is increasingly used in cosmetics: it has shown remarkable effectiveness in combating bags and dark circles in both men and women. 

 Lipotec, the company that produces Acetyl tetrapeptide-5, emphasizes that the peptide can combat particularly swollen eye bags by working on different mechanisms, such as the improvement of the vascular system and the skin strengthening under the eyes, effectively preventing also the accumulation of liquids. 

How does Eyeseryl© work for bags under the eyes and dark circles? 

The deterioration of the tissues around the eyes leads to an inevitable loss of elasticity, the accentuation of wrinkles, and the onset of thinner and more transparent skin. This occurs due to glycation. Glycation happens when too much sugar is consumed, for example, which interacts abnormally with fats and proteins, producing advanced glycation end products or AGE.

These AGEs act by destroying collagen and elastin, proteins that keep the skin firm and elastic. Eyersyl stops this process by targeting the proteins involved in the glycation process, the same ones that seek partners to complete the process: but the peptide replaces them and halts the process.

L’Acetyl Tetrapeptide 5 combats another cause of puffy eyes: water accumulation. Due to poor lymphatic circulation and high capillary permeability, the under-eye area tends to swell and darken: Eyeseryl© reduces the permeability of blood vessels in the eye area and for this reason, fluids do not accumulate in this area.

The accumulation of water, or eyelid edema, is one of the most difficult imperfections to combat, but Acetyl Tetrapeptide 5 has shown extraordinary effectiveness in reducing puffiness and dark circles under the eyes, also helping in the prevention of their reappearance.



The tests showed a reduction in the appearance of bags under the eyes of 70% in volunteers in just 28 days, in some cases it only took 14 days. The dark circles also significantly decreased and the appearance of skin elasticity around the eyes increased by 30% in 30 days.

Formula Eyes Duo Peptide LeLang

LeLang, always attentive to innovation in the cosmetic field, has perfected its formula for the eye contour by leveraging the properties of Acetyl Tetrapeptide 5.

Formula Eyes Duo Peptide by LeLang is a specific eye contour serum for bags, dark circles, and expression lines, essential for enhancing the effects of daily skincare for both women and men.

The contained peptides, Acetyl Hexapeptide-8 and Acetyl Tetrapeptide-5, represent the perfect combination of two bioactive molecules with anti-wrinkle action. The first acts in the communication between nerves and mimic muscles, reducing expression wrinkles. Acetyl Tetrapeptide-5 acts as an ACE (Angiotensin Converting Enzyme) converter and improves blood flow and lymphatic drainage, reducing bags and swelling under the eyes.

Furthermore, Eyes Duo Peptide is enriched with high and medium molecular weight hyaluronic acid, moisturizing Organic Aloe Vera juice, vitamin B3, and caffeine, a powerful vasoconstrictor capable of making the capillaries under the eyes less visible and naturally brightening the area.

Thanks to the effectiveness of the active ingredients, the serum LeLang Formula Eyes Duo Peptide acts on the skin by smoothing it and making it toned and stretched, free of puffiness or visible capillaries.