Munapsys™ is a next-generation biomimetic peptide, developed using in silico molecular design techniques to reproduce a relaxing effect on facial muscles in cosmetic and topical form.
Its INCI name is Acetyl Hexapeptide-1, and it stands out in the field of neurocosmetics for its mechanism of action, which involves both nerve transmission (the pre-synaptic phase) and the muscle response (the post-synaptic phase).
[INDICE:h2]
What is Munapsys™: origin and design
Munapsys™ was developed using an approach known as in silico design, which uses computational algorithms to simulate interactions between molecules and target proteins. The peptide was optimized to compete with the Munc-18 protein, a key component of the SNARE complex, interfering with acetylcholine release, which is fundamental to muscle contraction.
It is made up of 99.4% ingredients of natural origin according to the ISO 16128 standard, comes as a highly soluble aqueous solution, and is used at concentrations between 2% and 5%.
The mechanism of action
Pre-synaptic action: acetylcholine release
In the neuromuscular system, contraction is triggered by the release of acetylcholine (ACh) from the motor neuron's synaptic vesicles. This release depends on the correct assembly of the SNARE protein complex, composed of Munc-18, syntaxin, SNAP-25, and VAMP.
Munapsys™ is designed to interfere with the Munc-18 protein, reducing its ability to bind to syntaxin and thus hindering the formation of the SNARE complex. The result is reduced acetylcholine release, with a mild, temporary, and reversible effect.
Post-synaptic action: the muscle response
The second feature of Munapsys™ concerns the muscle. Unlike Argireline® (Acetyl Hexapeptide-8), which acts only at the level of nerve signaling, this peptide also modulates the expression of genes involved in muscle contraction.
In experimental models using human myocytes, the manufacturer reports a reduction in intracellular calcium mobilization, myosin levels, and the expression of certain contractile genes (ATP2A, TNNC1, MYH1, ACTA1, CACNB1, SCN3A).
This dual level of action — pre- and postsynaptic — is what distinguishes Munapsys™ from other relaxing peptides on the market.
Data reported by the manufacturer
The test portfolio includes in vitro tests on neuronal and muscle cell models, ex vivo tests on neuron-myofiber cocultures, and in vivo tests on a group of volunteers aged 35 to 55.
The in vitro tests report reduced Munc-18/syntaxin interaction, decreased exocytosis in neurons, and lower myosin levels in treated myocytes.
In the clinical test, conducted for 14 days on 18 volunteers using a 3% cream and assessed with PRIMOS and VISIA instruments, the manufacturer reports a reduction in roughness and expression wrinkle depth, with results observable as early as the first week.
As with all patented cosmetic active ingredients, these data come from tests conducted by the ingredient manufacturer and not from independent clinical studies published in peer-reviewed journals. The sample in the in vivo test was also small (18 subjects), and the study was short: these findings indicate potential efficacy in a formula, not definitive proof. The mechanism of action on the SNARE complex is, however, described in the scientific literature.
Which wrinkles it targets
Munapsys™ delivers the best results on dynamic wrinkles, those caused by the repeated movement of facial muscles:
- Glabellar lines, between the eyebrows;
- Forehead lines;
- Crow's feet;
- Perioral wrinkles.
Its effect is more limited on static wrinkles already formed in the dermis due to the loss of collagen and elastin: in that case, active ingredients that work on the dermal matrix are needed, such as signal peptides or collagen stimulators.
Safety and tolerability
According to the safety data provided by the manufacturer, Munapsys™ showed no skin or eye irritation in in vitro tests on reconstructed epidermis, no sensitizing potential in the HRIPT test, and good formula stability. It can therefore also be used on sensitive skin.
Munapsys™ in LeLang’s Multi Peptide Lift
We chose this peptide for Multi Peptide Lift — Botoxil Technology, an intensive facial serum designed to smooth expression lines without invasive treatments.
MULTI PEPTIDE LIFT FORMULA - BOTOXIL TECHNOLOGY Anti-wrinkle face serum with Botoxil Technology® Two biomimetic peptides for expression lines, biotechnological resve... Discover MULTI PEPTIDE LIFT FORMULA - BOTOXIL TECHNOLOGY
Use it as a daily serum before face cream. It’s suitable for people in their thirties and older with pronounced expression lines or those who prefer a non-invasive approach.
As with all peptides, the effect depends on consistent use: when you stop applying it, the muscles gradually return to their usual behavior.
An important clarification. Functional skincare is not a substitute for aesthetic medicine. A topical peptide acts on the skin’s surface, with much lower intensity and in a reversible way compared with an injectable treatment, which is a medical procedure. Munapsys™ is an effective at-home regimen, which can be combined with aesthetic medicine, or an alternative for those seeking non-invasive solutions—but it’s not the same thing and shouldn’t be presented as such.
The Acetyl Hexapeptide-1 ingredient page lists all LeLang formulas that contain it.
You can also find LeLang products at our partner pharmacies throughout Italy.
Frequently asked questions
What’s the difference between Munapsys™ and Argireline®?
Both act on signal transmission that triggers muscle contraction, but they target different proteins: Argireline® interferes with SNAP-25, while Munapsys™ acts on Munc-18 and also works downstream, on the muscle cell’s response.
How long does it take to see results?
The manufacturer’s tests report instrumentally measurable changes within two weeks. Consistent use over several weeks is needed for a visible effect.
Is it suitable for sensitive skin?
Yes, tolerance tests found no potential for irritation or sensitization. During pregnancy and breastfeeding, as with all cosmetic ingredients, it’s best to consult your doctor.
Free 15-Minute Consultation with the Founder
Want to find out whether a peptide treatment is right for your expression lines? Book a free virtual skincare consultation with Elisa Avalle, founder of LeLang.
