What Is Acetyl sh-Hexapeptide-5?
L'Acetyl sh-Hexapeptide-5 Amide Acetate, commercially known as Versillin™, is a synthetic biomimetic peptide that replicates part of versican, a molecule in the dermal matrix. Versican retains water in the space between cells, binds to hyaluronic acid and fibrillin, and helps organize the microfibrils from which elastic fibers form.
How It Works on Beauty Columns
In the dermis, bundles of connective tissue called beauty columns anchor the skin to deeper layers, like the roots of a tree. Over the years, this network loosens and the facial contour loses definition, especially along the jawline.
The peptide supports the matrix components that hold this structure together, namely versican, fibrillin, and elastic fibers, and helps prevent their degradation. The result is skin that looks more firm, elastic, and cohesive, with a more defined-looking facial contour.
Which Skin Types Is It Suitable For?
It's designed for mature skin that has lost tone and support: a less defined facial contour, with sagging cheeks and jawline. It's used in a serum, morning and evening, on the face and neck. It's a certified vegan ingredient that was found to be non-irritating and non-sensitizing in safety tests.
What to Pair It With
It works best with actives that target collagen: in the dermis, the collagen network provides strength, elastic fibers help skin bounce back, and facial firmness depends on both. That's why it features in serums formulated around collagen, where it complements the action of peptides that support its production.
Find out more on our blog aboutelastin and its role in skin elasticity.
Frequently asked questions
What is Versillin?
It is the trade name for Acetyl sh-Hexapeptide-5 Amide Acetate, a synthetic peptide that replicates a portion of versican, the molecule that retains water in the dermis and organizes elastic fibers.
What are beauty columns?
These are bundles of connective tissue that anchor the skin to deeper layers. When they loosen, the facial contour loses definition: the peptide supports the matrix components that hold them together.
What does Acetyl sh-Hexapeptide-5 pair with?
With actives that work on collagen: collagen and elastic fibers work together, and facial firmness depends on both.
Is it suitable for sensitive skin?
It was found to be non-irritating and non-sensitizing in safety tests, and it is a certified vegan ingredient.
The selection of ingredients is curated by Elisa Avalle, founder of LeLang and a dermocosmetics specialist. Each formula is created and developed in LeLang laboratories.
