What are plant-based collagen fragments
Col-Frag Remastered™ is the name of a patented biotech active, listed in the INCI as Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-47. It is neither a synthetic peptide nor a plant extract: it is a fragment of collagen produced by a plant. The name says it all — Col-Frag stands for collagen fragment — and it is one of the latest technologies available in dermocosmetics.
How it works on the skin
The Nicotiana benthamiana plant is induced to produce the sequence through a process called transient expression: the protein is synthesized without genetically modifying the plant. The fragment replicates a portion of human collagen, which fibroblasts recognize as a signal to remodel the matrix and respond by producing their own collagen. This is a different mechanism from that of signal peptides: here, a message isn't imitated; the authentic fragment is provided.
What it's for and how to use it
It works on loss of firmness and wrinkles caused by structural sagging, which are linked to thinning of the dermis. Use it in a serum, morning and evening. Like all active ingredients that work on fibroblasts, it requires consistent use: four to eight weeks.
Safety and environmental profile
The ingredient's technical dossier documents a comprehensive safety profile using standardized methods — non-irritating, non-phototoxic, non-mutagenic — and notable environmental data: 85% biodegradable in twenty-nine days, non-ecotoxic, and certified vegan and halal. This is a rare combination of documented efficacy and low environmental impact.
On our blog, you can read more about plant-based biotech collagen and how it is produced.
Frequently asked questions
What is plant-based collagen?
It is a human collagen fragment produced by the plant Nicotiana benthamiana through transient expression: the plant synthesizes the protein without being genetically modified.
What is the difference between collagen fragments and signal peptides?
Signal peptides mimic a message; the collagen fragment, on the other hand, provides the authentic portion of human collagen, which fibroblasts recognize and respond to by producing their own collagen.
How do you use a serum with plant-based collagen?
Apply morning and evening. Like all actives that work on fibroblasts, it requires consistency: results appear over the course of one to two months.
Is plant-based collagen vegan?
Yes, the ingredient is certified vegan and halal, and it is not ecotoxic. Its technical dossier also documents a comprehensive safety profile.
The selection of ingredients is curated by Elisa Avalle, founder of LeLang and a dermocosmetics specialist. Each formula is created and developed in LeLang laboratories.
